采用兼容大规模量产技术的柔性电子印刷技术可以实现大面积类皮肤传感器件的构建。采用具有可逆连接能力的柔性电路对于多导联心电信号进行医疗级别的测量，电路可以通过磁电复合接口实现与柔性传感器的快速互连。为全面解析心脏系统在静态和动态下的状态，预测心脏系统的疾病提供了重要的工具。

Printing electronic technology that is scalable to yield mass fabrication of flexible electronics has been used to develop large area multilead sensors for healthcare applications. Using reversible connection between the sensors and the flexible circuits, continuous monitoring of human health conditions in static and dynamic states become feasible. The result can be used to predict health conditions and provide diagnosis suggestion for cardiovascular diseases.

基于无机可延展结构和本征柔性材料，构建多功能多参数的柔性可延展器件，这类器件具有与皮肤共同运动和抗运动干扰的特性，可实现包括心率、心电、温度、水分、血氧、脉搏、应变等物理量以及汗液中离子、葡萄糖、乳酸等成分的测量。我们实现了长达七天的连续检测和大量生理参数的获取。

The epidermal electronics are constructed by unique structures of inorganic materials and intrinsic soft organic materials. These types of electronics can deform together with human skin with improved capability to withstand motion artifacts. We have achieved various multifunctional and multichannel devices that can sense physical parameters such as heart rate, biopotential, temperature, humidity, oxygen level, pulse rate, and stress and chemical parameters such as ion, glucose, and lactate. The devices can work continuously for more than 7 days and have collected large numbers of data.

生物可吸收电子器件是一种新型信息器件，它打破了传统电子器件长期存在难以回收的固定形态。我们不但获得了基于CMOS的生物可吸收的电子器件，还建立了基于印刷和打印技术的瞬态器件，我们提出的水烧结的技术，可以在室温和常压下提升打印油墨的电学性能，从而使得生物可吸收的电子器件达到了常规电子器件的性能，实现了消费类电子级别的瞬态电路。

Bioresorbable electronic device is a new type of information device, which breaks the long-standing fixed form of traditional electronic device that is difficult to be recycled. We have not only obtained CMOS-based bioabsorbable electronics, but also established printing transient devices. We proposed the water sintering technology that can improve the electrical performance of printing inks at room temperature and normal pressure. The bioresorbable electronic devices have reached the performance of conventional electronic devices, and a transient consumer electronic device has been realized.

基于双金属水烧结的方法，实现了生物可吸收电路，电路中的导线的性能达到了接近于纯金属性能的水平，使得可降价可溶解的电路获得了与传统电路一样的性能，可以替代传统不可降解的电路进行消费类电子产品的制作，实现电子垃圾的快速回收。

Basing on the bimetal water sintering apporach, high performance bioresorbable circuits have been realized. The conductors in the circuits have matching conductivity as pure metals, making the bioresorbable circuits as good as conventional circuits. The technique can be used to replace conventional circuits to make consumer electronics to faciliate rapid recycling of the circuit componnents.

研制多导联多参数高通量的柔性可植入式电子器件，对人体组织中的电学和化学参数进行测量与调控。通过金属有机框架、酶、离子选择性薄膜、适配体等实现了选择性强的化学量测量，通过光电刺激实现电学活动和化学物质调控。这些器件可从系统的层面了解动物体的工作机制，可给脑机接口、无人系统控制、神经系统疾病治疗、肿瘤治疗提供重要手段。

We have developed multi-lead, multi-parameter and high-throughput flexible implantable electronic devices, and use these devices to measure and regulate electrical and chemical parameters in human tissues. Highly selective chemical measurement can be achieved through metal-organic frameworks, enzymes, ion-selective membranes,and aptamers. Electrical and photonic stimulation can be used to regulate electrical and chemical activities. These devices help to understand the working mechanism of the animal body from the system level, and can provide important apporaches for the brain-computer interface, unmanned system control, neurological disease treatment, and tumor treatment.

基于永磁稀土纳米和微米颗粒构建复合材料，实现柔性磁性薄膜和柔性器件，替代了传统大型生物医学诊疗系统。我们提出了通过折叠的方式定义磁性薄膜磁场方向的方法以及采用边缘效应增强磁场强度的技术。已经实现了包括柔性机器人、传感器、离心泵、肿瘤治疗、神经系统探测等基于磁性薄膜的柔性器件。

Permanent magnetic rare earth nano and micro particles have been used to prepare composite materials, which can be used to realize flexible magnetic membranes and magnetic devices. We propose methods to define the magetic polarities through origami apporaches and magnetic field enhancement through edge effect. Flexible devices based on magnetic films such as soft robots, sensors, centrifugal pumps, tumor treatment, and nervous system detection, have been realized.

基于稀土材料构建的磁性薄膜折叠技术构建的转子，通过电磁铁的驱动形成在液体中的磁悬浮柔性离心泵，用于驱动心脏系统疾病和肾病等疑难疾病中的血液、透析液的体外循环供应，实现了传统大型机械设备的柔性化和小型化，为实现可穿戴或可植入的人工器官奠定了基础。该柔性磁悬浮柔性离心泵是目前世界上最小和最轻的可在临床诊疗中使用的离心泵。

Flexible and miniaturized centrifugal pumps based on rotators made of origami magnetic membranes and electromagnets have been achieved. The pumps can be magnetically levitated through the magnetic force between the electromagnets and the rotators. The pumps can be used in cardiovascular diseases and kidney failure for blood and dialysis fluid circulation. The pumps have demonstrated the capability to achieve turn conventional mechanical systems into small and flexible devices. These centrifugal pumps are the smallest and lightest centrifugal pumps that can be practically used in clinic applications.

超声和超声微泡介导的靶向药物递送技术具有适用广泛、高效、安全等特点，尤其适合靶向递送毒副作用较强的抗癌药物。我们开展了从细胞到组织的多层面多角度的机理性研究，揭示了其发生的细胞生物学和微泡动力学机理，推动了该技术的发展及其临床转化。

Ultraound and microbubbles mediated intracellular delivery technique is a versatile, effective and safe targeted drug delivery method, especially suitable for targeted delivery of cytotoxic chemotherapeutic agents for cancer treatment. We have investigated the biological and physical mechanisms underlying this technique from the cellular level to the tissue level. By providing new insights in the mechanisms, our studies promote the development of this technique and its clinical translation.

通过综合运用声表面波、声学微结构等微声学技术，我们开发了高精度、高通量的超声镊细胞调控技术，并将其应用于干细胞的命运调控、神经细胞修复等方面。我们的工作有望为包括干细胞定向分化在内的多种细胞功能调控提供高精度、高通量的技术手段。

We have developed advanced acoustic tweezing cytometry using surface acoustic waves and microstructure acoustics. By integrating with cell culture ablility, advanced acoustic tweezing cytometry is applied to stem cell fate modulation, injured neuron repairment and so on. Our work provides a precise and high-throughput cell function regulation technique, with numerous applications including stem cell differentiation.

研究用于生物医学领域的液态金属柔性电子制备技术和应用方案，开发出多层大面积电路、拉伸传感器、可穿戴电子纹身以及医学影像辅助设备等一系列的功能性柔性电子电路。

We have developed the preparation of liquid metal flexible electronic in biomedical field, and develop a series of functional flexible electronic circuits, such as multilayer large area circuit, stretch sensor, wearable electronic tattoo and medical image auxiliary equipment, which show good electrical characteristics and broad application prospects in biomedical field.

本研究开发了一种大面积瞬态Van der Waals薄膜和器件的制备方法，利用光脉冲烧结和转印技术获得基于多层二维材料的瞬态薄膜，通过改变光脉冲的驱动电压和脉冲宽度可以调控瞬态薄膜的各种特性。基于这种技术的瞬态薄膜可用作可降解的可抛式心电电极。通过两步烧结方法可以直接将瞬态薄膜进行图案化，线宽可达100 µm。本研究采用的光脉冲烧结方法满足低温和无水条件的要求，兼容瞬态电子器件的制造工艺，可用于制备各种大面积的瞬态Van der Waals薄膜和器件。这些瞬态器件将进一步丰富瞬态电子学的范畴。

A photonic sintering method for large-area transient van der Waals (vdW) films and devices was developed. A two-step sintering method was developed to directly pattern the transient films with a linewidth of 100 µm. Transient electronics based on other vdW thin films such as graphene and MoS2 can be fabricated by the same approaches through combining photonic sintering and direct transferring. It can be expected that more and more transient electronics based on vdW thin films that are processed by the photonic sintering may appear. These transient devices will further enrich the scope of transient electronics and reduce the consumption of time, energy, and resource.

我们研究基于信息融合、模式识别、深度学习等技术的计算机辅助个体化诊疗。目前的主要研究课题包括：多参数MRI图像中肿瘤自动分割方法，基于CT-PET图像深度学习的淋巴瘤病灶自动分割和治疗效果预测，基于医学图像和临床特征的乳腺癌诊断和预后预测等。

We work on developing personalized computer-aided diagnosis and prognosis systems by using image processing, information fusion, pattern recognition methods in various medical fields. Currently, we focus on the following research topics, tumor segmentation in multi-parametric MRI images, deep learning of CT-PET images for lymphoma segmentation and outcome prediction, multimodality medical images and clinical information based breast cancer personalized diagnosis and prognosis.